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2 edition of Pulmonic alveolar epithelium found in the catalog.

Pulmonic alveolar epithelium

Charles C. Macklin

Pulmonic alveolar epithelium

A round table conference.

by Charles C. Macklin

  • 324 Want to read
  • 12 Currently reading

Published in St. Louis .
Written in English


Edition Notes

From the Journal of thoracic surgery, 6.

Other titlesJournal of thoracic surgery.
The Physical Object
Pagination8 p. ;
ID Numbers
Open LibraryOL19390907M

Type II avleolar epithelial cells secrete pulmonary surfactant to lower the surface tension of water, which helps prevent airway collapse. Reinflation of the alveoli following exhalation is made easier by pulmonary surfactant. The surfactant reduces surface tension within all alveoli through hydrophilic and hydrophobic forces.   The pulmonary arterial circulation originates from the right side of the heart. Histologically, pulmonary arteries and veins are often adjacent to bronchi and larger bronchioles. These vessels progressively divide into smaller caliber vessels and, terminally, form a network of capillaries that course through alveolar septa and function in gas Author: Ryan Jennings, Christopher Premanandan.

  In , Mason and Williams developed the concept of the alveolar epithelial type II (AE2) cell as a defender of the alveolus. It is well known that AE2 cells synthesise, secrete, and recycle all components of the surfactant that regulates alveolar surface tension in mammalian lungs. AE2 cells influence extracellular surfactant transformation by regulating, for example, pH and [Ca2+] of the Cited by:   Mechanisms of injury and repair in alveolar epithelial cells (AECs) are critically involved in the progression of various lung diseases including idiopathic pulmonary fibrosis (IPF). Homeobox only Cited by: 8.

Convincing evidence has emerged demonstrating that impairment of mitochondrial function is critically important in regulating alveolar epithelial cell (AEC) programmed cell death (apoptosis) that may contribute to aging-related lung diseases, such as idiopathic pulmonary fibrosis (IPF) and asbestosis (pulmonary fibrosis following asbestos exposure). The mammalian mitochondrial DNA (mtDNA Cited by: Idiopathic pulmonary fibrosis (IPF) • Usual interstitial pneumonia (UIP) • Alveolar epithelial cells (AEC) • Telomerase • Forced vital capacity (FVC) Research Article. Type II Alveolar Epithelial Cells in Remodeled Areas of. Idiopathic Pulmonary Fibrosis/ Usual Interstitial Pneumonia. Barbas-Filho JV. 1, Parra ER. 2, Waisberg DR. 1.


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Pulmonic alveolar epithelium by Charles C. Macklin Download PDF EPUB FB2

Lung Epithelial Biology in the Pathogenesis of Pulmonary Pulmonic alveolar epithelium book provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease.

The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, Pulmonic alveolar epithelium book the molecular basis of lung epithelial intercellular communication and lung epithelial Price: $ RESIDUAL EPITHELIAL CELLS ON THE PULMONARY ALVEOLAR WALLS OF MAMMALS [Charles C Macklin] on *FREE* shipping on qualifying : Charles C Macklin.

The section on physiology relating to the pulmonary parenchyma expands upon the discussion of gas exchange at the alveolar level that is covered in Chapter 1. Additionally, the concept of compliance as the relationship between distending pressure and lung volume is reviewed, and the shifting of compliance curves in diffuse parenchymal lung disease downward and to the right is described.

Alveolar macrophages (AM) also known as dust cells are a type of white blood cells. The immune system is divided into the cellular and humoral components. Alveolar macrophages are the first line of defense against invading respiratory pathogens.

They reside in pulmonary alveoli and the inter-alveolar septum in close proximity with : Ahmed Naeem, Sachchida N. Rai, Louisdon Pierre. Pulmonary alveolar epithelial cells (PAEpiC) comprised of alveolar type I and type II epithelial cells, line more than 99% of the internal surface area of the lung.

Type I cells are large squamous cells whose thin cytoplasmic extensions cover >95% of the internal surface area. They contain aquaporins and exhibit the highest osmotic water.

The Alveolar Epithelium and Pulmonary Fibrosis Article in Journal of Epithelial Biology & Pharmacology 2(1) September with 16 Reads How we measure 'reads'Author: Huiping Li.

Pulmonary alveolar epithelial cells (PAEpiC), comprised of alveolar type I and type II epithelial cells, line more than 99% of the internal surface area of the lung [1].

Type I cells are large squamous cells whose thin cytoplasmic extensions cover >Price: $ Rapid improvement in abnormal pulmonary epithelial permeability after stopping cigarettes Article (PDF Available) in British Medical Journal (Clinical research ed.) () May response of the airway epithelium after injury.5 In con-trast, the alveolar surfaces in the peripheral lung are lined by flat alveolar epithelial type 1 cells (AEC1) that form a continuous cell layer and are specialized in gas exchange, while cuboidal alveolar epithelial type 2 cells (AEC2) act as progenitor cells and secrete pulmonaryAuthor: Rachele Invernizzi, Clare M.

Lloyd, Philip L. Molyneaux. Purpose. To develop a cell culture model of human alveolar epithelial cells in primary culture for the in vitro study of pulmonary absorption and transport. Methods. Type II pneumocytes isolated from normal human distal lung tissue by enzyme treatment and subsequent purification were plated on fibronectin/collagen coated polyester filter inserts, and cultured using a low-serum growth Cited by: Alveolar epithelial cells (AECs) of the lung importantly contribute to pulmonary immune functions and to pulmonary development and alveolar repair mechanisms following lung injury.

AECI, together with the capillary endothelium, form the extremely thin barrier between alveolar air and blood. Alveolar macrophages have been investigated for years by approaches involving macrophage extraction from the lung by bronchoalveolar lavage, or by cell removal from lung tissue.

Since extracted macrophages are studied outside their natural milieu, there is little understanding of the extent to which alveolar macrophages interact with the epithelium, or with one another to generate Cited by:   Abstract. Idiopathic pulmonary fibrosis (IPF) is characterised by repeated injury to the alveolar epithelium with loss of lung epithelial cells and abnormal tissue repair, resulting in excessive accumulation of fibroblasts and myofibroblasts, deposition of extracellular matrix components and distortion of lung architecture, eventually leading to respiratory by: The aim of the present study is to investigate the protective effect of GB on lipopolysaccharide‐induced inflammatory responses in A human pulmonary alveolar epithelial cells (HPAEpiC) in vitro.

Cell viability and apoptosis were measured by CCK‐8 and flow : Yijin Xiang, Shaoyan Zhang, Jia Lu, Wen Zhang, Min Cai, Jun Xiang, Dingfang Cai. Idiopathic pulmonary fibrosis is a progressive disease of unknown etiology characterized by a dysregulated wound healing response that leads to fatal accumulation of fibroblasts and extracellular matrix (ECM) in the lung, which compromises tissue architecture and lung function capacity.

Injury to type II alveolar epithelial cells is thought to be the key event for the initiation of the disease Cited by: The Pulmonary Epithelium offers a comprehensive overview of the structure and function of this tissue, in health and disease.

This text brings together in a single volume, the body of knowledge that currently exists, and explores how this knowledge may be applied in the future to increase our understanding of disease and to develop new types of treatment. Alveolar epithelial cell (AEC) injury leading to cell death is involved in the process of fibrosis development during idiopathic pulmonary fibrosis (IPF).

Among regulated/programmed cell death, the excessive apoptosis of AECs has been widely implicated in IPF pathogenesis. Necroptosis is a type of regulated/programmed by: 9. Gas exchange: Alveoli Alveoli. Alveoli (singular: alveolus) are the site of gas exchange in the lung.

Alveoli are thin-walled, sac-like structures lined by a single layer of flattened squamous epithelial cells: type I pneumocytes. This extremely thin nature of the type I pneumocytes facilitates gas exchange across their : Ryan Jennings, Christopher Premanandan. Using this atlas, we demonstrated heterogeneity within alveolar macrophages and epithelial cells from subjects with pulmonary fibrosis.

Pulmonary fibrosis is defined as the progressive replacement of alveolar tissue with fibrotic scar that threatens alveolar gas exchange and reduces lung compliance ( Cited by: Briefly, Human alveolar epithelial type II cells were isolated from explanted lungs or human lungs not used by the Northern California Transplant Donor Network.

The pulmonary artery was perfused with PBS and distal airspaces lavaged several times with by:. This review discusses current knowledge of the involvement of the alveolar epithelium in tissue remodelling during fibrogenesis.

The purpose of the present paper is to give an overview, including the authors' own results, of knowledge of ultrastructural alterations, proliferation kinetics and phenotypic changes of pneumocytes in experimental and clinical pathology of pulmonary fibrosis.Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease Surafel Mulugeta,1 Shin-Ichi Nureki,2 and Michael F.

Beers1 1Pulmonary, Allergy, and Critical Care Division; Department of Medicine, University of Pennsylvania Perelman. Rationale Alveolar type II (ATII) cells act as adult stem cells contributing to alveolar type I (ATI) cell renewal and play a major role in idiopathic pulmonary fibrosis (IPF), as supported by familial cases harbouring mutations in genes specifically expressed by these cells.

During IPF, ATII cells lose their regenerative potential and aberrantly express pathways contributing to epithelial Author: Silvia Moimas, Francesco Salton, Beata Kosmider, Nadja Ring, Maria C. Volpe, Karim Bahmed, Luca Brag.